A method to visualize transdermal nickel permeation in mouse skin using a nickel allergy patch

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A method to visualize transdermal nickel permeation in mouse skin using a nickel allergy patch

Metal patch test is often used in clinical settings when metal-induced contact dermatitis is suspected. However, the transdermal permeation behavior of metal ions from the patch test remains unclear. Current patch tests using high concentrations of metal salt solutions have some side effects, e.g. acute skin reactions to high concentrations of metal salt. To resolve these, estimating metal ion ...

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A study of nickel allergy.

N ickel is a potentially allergenic material. It is one of the most common causes of allergic contact dermatitis, particularly in women. l-5 Nickel can also be considered an occupational allergen. Nickel contact dermatitis is common among industrial workers, especially in those industries that use nickel as a raw material. It has been demonstrated that U.S. S-cent coins contain approximately 25...

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[Mechanisms of nickel allergy].

Nickel allergy constitutes a serious health problem of modern societies. Hypersensitivity to this metal is found in 13% adults and 8% children. Risk factors for nickel allergy are: female gender and early exposure to nickel, e.g. piercing. Various mechanisms of inducing nickel allergy are possible, which is also reflected in the different clinical pictures. Nickel can induce allergic reaction i...

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Systemic nickel allergy syndrome

Methods Demonstrate SNAS which is characterized by contact dermatitis to nickel and systemic reactions after ingestion of rich foods nickel.We evaluated adult patients with ages between 18 and 65 years, positive patch test for nickel, grades 3 and 4, and who had symptoms suggestive of SNAS.These patients had eczematous lesions of contact dermatitis did not disappear. That even with the exclusio...

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Nickel oral hyposensitization in patients with systemic nickel allergy syndrome

BACKGROUND This is the first randomized, double-blind, placebo-controlled trial (EUDRACT No. 2009-013923-43) evaluating nickel oral hyposensitizing treatment (NiOHT) in patients with "systemic nickel allergy syndrome" (SNAS), characterized by Ni-allergic contact dermatitis and systemic reactions after eating Ni-rich food. METHODS Adults with positive Ni-patch test, who reported symptoms sugge...

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ژورنال

عنوان ژورنال: Bio-Medical Materials and Engineering

سال: 2015

ISSN: 1878-3619,0959-2989

DOI: 10.3233/bme-151543